zGH Mutant

Alternative Names: Pituitary growth hormone, Somatotropin, GH1, GH, GHN, GH-N, hGH-N, Growth hormone 1.

GH is a hormone involved in growth control and belongs to the somatotropin/prolactin family. It is located on chromosome 17 along with four other genes, and they have evolved through gene duplications. The five genes have similar sequences and can be alternatively spliced to produce different isoforms of growth hormones. While this particular gene is expressed in the pituitary, the other four genes are expressed in placental tissue. Mutations or deletions of this gene can lead to growth hormone deficiency and short stature.

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  • Sku: PSB-cyt-709-10µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

The Recombinant Zebrafish Growth Hormone Mutant is a genetically modified zebrafish strain that exhibits altered growth hormone activity. Belonging to the family of Cyprinidae, this mutant strain has been engineered to possess specific mutations in its growth hormone gene, resulting in impaired growth regulation. With regards to weight, the Recombinant Zebrafish Growth Hormone Mutant showcases a distinct deviation from the normal weight range observed in wild-type zebrafish. This genetically modified zebrafish strain serves as a valuable model organism for studying the intricate mechanisms involved in growth regulation and hormone signaling pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
Zebrafish
Expression System E. coli
Purity 99.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein was lyophilized from a concentrated (1mg/ml) solution with 0.5% NaHCO3 pH-8.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Gln-Arg-Leu-Phe-Asn.

Storage Instruction

Lyophilized Growth-Hormone although stable at room temperature for at least two weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization GH can be stored at 4°C, pH 9 for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Zebrafish Mutant G113R in 0.4% NaHCO3 or water adjusted to pH-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in a presence of a carrier protein such as BSA or similar.

References

Not Available

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zGH Mutant

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