XRCC3

Alternative Names: X-ray repair cross complementing protein 3, RAD51-like, X-ray repair cross complementing protein 3, RAD51-like.

Recombinant Human X-Ray Repair Cross Complementing Protein 3 (XRCC3) is a member of the RecA family and RAD51 subfamily. It plays a key role in homologous recombination, which helps maintain chromosome stability and repair DNA damage. XRCC3 is known to complement Chinese hamster irs1SF, a mutant that is deficient in repair mechanisms and exhibits hypersensitivity to various DNA-damaging agents, leading to chromosomal instability.

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  • Sku: PSB-pro-2649-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human X-Ray Repair Cross Complementing Protein 3 (XRCC3) is a DNA repair protein involved in the homologous recombination pathway. Belonging to the RecA/Rad51 protein family, XRCC3 plays a critical role in maintaining genomic stability by facilitating the repair of double-strand breaks in DNA. With a molecular weight of approximately 38 kDa, XRCC3 interacts with other proteins to form nucleoprotein filaments that mediate the exchange of genetic material between homologous DNA strands. This recombinant protein is widely used in scientific research to investigate DNA repair mechanisms and their implications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The XRCC3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFRCEFDSQASAP RARHLQSLGA TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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XRCC3

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