XPA

Alternative Names: XPAC, XP1, DNA repair protein complementing XP-A cells.

XPA, a DNA repair protein, is involved in the process of DNA excision repair. It binds to damaged sites with varying affinities, depending on the type of damage and the transcriptional state of the region. Mutations in XPA lead to xeroderma pigmentosum complementation group A (XP-A), a rare autosomal recessive disease in humans. XP-A is characterized by sensitivity to sunlight, a high risk of developing skin cancer in sun-exposed areas, and potential neurological abnormalities.

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  • Sku: PSB-pro-026-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Xeroderma Pigmentosum, Complementation Group A (XP-A) is a protein that plays a vital role in DNA repair mechanisms. Belonging to the nucleotide excision repair (NER) family, XP-A protein is responsible for identifying and removing DNA lesions caused by ultraviolet (UV) radiation and other mutagenic agents. With a molecular weight of approximately 38 kilodaltons, this protein is involved in maintaining genomic integrity and preventing the accumulation of DNA damage. Its significance lies in its ability to repair DNA lesions, making it an important component in safeguarding against the development of skin cancers and other UV-induced genetic disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation XPA protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAAADGA LPEAAALEQP AELPASVRAS IERKRQRALM LRQARLAARP YSATAAAATG GMANVKAAPK IIDTGGGFIL EEEEEEEQKI GKVVHQPGPV MEFDYVICEE CGKEFMDSYL MNHFDLPTCD NCRDADDKHK LITKTEAKQE YLLKDCDLEK REPPLKFIVK KNPHHSQWGD MKLYLKLQIV KRSLEVWGSQ EALEEAKEVR QENREKMKQK KFDKKVKELR RAVRSSVWKR ETIVHQHEYG PEENLEDDMY RKTCTMCGHE LTYEKM .

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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XPA

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