WWOX

Alternative Names: WWOX, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, D16S432E, WWOX, WOX1

WWOX is a proapoptotic and tumor suppressor protein found in all eukaryotes. It plays a role in regulating various cellular functions such as protein degradation, transcription, and RNA splicing. WWOX works in conjunction with TP53/p53 to control genotoxic stress-induced cell death and is involved in TNF-mediated cell death. Loss of WWOX expression is linked to pancreatobiliary cancers, basal-like differentiation in breast cancer, extrahepatic cholangiocarcinoma, and early genetic alterations in oral carcinogenesis. WWOX induces apoptosis and inhibits human hepatocellular carcinoma cell growth through a mechanism that is enhanced by JNK inhibition.

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  • Sku: PSB-enz-422-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human WW Domain Containing Oxidoreductase is a protein belonging to the WW domain-containing oxidoreductase family. This protein plays a role in various cellular processes, including signal transduction and protein-protein interactions. With a molecular weight of approximately 40 kDa, Recombinant Human WW Domain Containing Oxidoreductase is involved in regulating the activity of numerous target proteins through its oxidoreductase activity. Its function is crucial for maintaining cellular homeostasis and proper functioning of various biological pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The WWOX solution (1mg/ml) contains 20mM Tris pH-8, & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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WWOX
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