TXNRD1 161-649

Alternative Names: Thioredoxin reductase 1 cytoplasmic, TXNRD1, Thioredoxin reductase TR1, TRXR1, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, GRIM12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, KDRF, MGC9145, TR, TR1, TXNR.

TXNRD1 is a member of the selenium-containing pyridine nucleotide-disulphide oxidoreductase family, with a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. It plays a role in decreasing thioredoxins and other substrates, as well as being involved in selenium metabolism and protection against oxidative stress. Inhibiting the activity of TXNRD1 has the potential to be used as a treatment for cancer, AIDS, autoimmune diseases, bacterial infections, and parasitic diseases.

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  • Sku: PSB-enz-042-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Thioredoxin Reductase 1 161-649 a.a. is a protein belonging to the thioredoxin reductase family. With a molecular weight of approximately [insert weight], this protein plays a significant role in cellular redox regulation and antioxidant defense mechanisms. It functions by catalyzing the reduction of oxidized thioredoxin, thereby maintaining its active form and enabling it to participate in various cellular processes. By employing recombinant technology, this specific form of thioredoxin reductase has been produced for research purposes, allowing scientists to investigate its structure, function, and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
55.9 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The TXNRD1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0) and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGCCG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TXNRD1 161-649

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