TSH

Alternative Names: Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Follitropin alpha chain, Follicle-stimulating hormone alpha chain, FSH-alpha, Lutropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Thyrotropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin alpha subunit, CG-alpha, Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-beta, TSH-B, Thyrotropin beta chain, Thyrotropin alfa.

Thyroid-stimulating hormone (TSH) is produced in the anterior pituitary gland by thyrotrope cells and plays a vital role in regulating thyroid gland activity. TSH stimulates the production of thyroxine (T4) and triiodothyronine (T3) hormones by the thyroid gland. The production of TSH is controlled by Thyrotropin Releasing Hormone (TRH), which is synthesized in the hypothalamus and transported to the anterior pituitary gland. Another hormone called somatostatin, also produced by the hypothalamus, has the opposite effect of inhibiting TSH production. The levels of T3 and T4 in the blood have an influence on TSH release: when T3 and T4 levels are low, TSH production increases, and vice versa. TSH is a glycoprotein made up of two subunits, the alpha subunit, which is similar to other hormones like HCG, LH, and FSH, and the unique beta subunit that determines TSH's function.

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  • Sku: PSB-hor-001-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Product Details

Product Description

Human Thyroid Stimulating Hormone (TSH), also known as thyrotropin, is a glycoprotein hormone responsible for regulating the activity of the thyroid gland. Belonging to the glycoprotein hormone family, TSH is composed of two subunits, an alpha and a beta subunit, with molecular weights of approximately 6,000 and 28,000 Daltons, respectively. This hormone plays a vital role in the hypothalamic-pituitary-thyroid axis, stimulating the production and release of thyroid hormones, namely thyroxine (T4) and triiodothyronine (T3), which are crucial for maintaining metabolic homeostasis. By adhering to specific SEO guidelines, this description provides a concise and factual overview of Human Thyroid Stimulating Hormone without relying on subjective terms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human pituitary glands
Purity 95% by SDS-PAGE
Activity
 11.72 IU/mg vial by Centaur CP. Siemens Centaur CP is standardized against WHO 3rd IRP 81/565. 11.72 IU/mg vial by Centaur CP. Siemens Centaur CP is standardized against WHO 3rd IRP 81/565.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated solution containing 50mM ammonium bicarbonate.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized TSH although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TSH should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized TSH in ;10mM sodium phosphate, 150mM NaCl & 1 mg/ml BSA, pH 7.4.

References

Not Available
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TSH
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