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Troponin C-I-T, Human

Alternative Names: Cardiac troponin I, Troponin I cardiac muscle, TNNI3, CMH7, RCM1, cTnI, CMD2A, MGC116817, Troponin C slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC, TNC, CMD1Z

The Troponin Complex is a crucial protein involved in controlling muscle contraction in both skeletal and cardiac muscles. It consists of three subunits - Troponin I, Troponin T, and Troponin C. Each subunit has a specific function within the complex. For example, Troponin I inhibits the activity of acto-myosin ATP-ase. It is important to note that the forms of Troponin T and Troponin I differ in cardiac and skeletal muscles. To study the Troponin Complex, researchers purify the individual subunits (rcTnI, rcTnC, and rcTnT) and then reassemble them in vitro under controlled conditions.

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  • Sku: PSB-pro-2741-25µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

The Human Cardiac Troponin C-I-T Complex is a regulatory protein complex found in the cardiac muscle tissue. It belongs to the troponin family, which comprises three subunits: troponin C, troponin I, and troponin T. This complex plays a crucial role in regulating cardiac muscle contraction by binding to calcium ions and facilitating the interaction between actin and myosin filaments. With a molecular weight of approximately 90 kDa, this complex is an important biomarker for diagnosing cardiac muscle damage, such as myocardial infarction, due to its release into the bloodstream upon cardiac injury.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human cardiac tissue
Purity
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Troponin C-I-T Complex solution (0.2µm filtered) contains 25mM TRIS buffer, 0.15M NaCl, 0.09% sodium azide, pH 7.5.

*For Research Use Only

Notes

Human Virus Test: Starting material donor has been tested and certified negative for antibodies to HIV-1, HIV-2, HCV, HBSAG, Syphilis and HIV/HBV/HCV.

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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Troponin C-I-T, Human
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