TREX2

Alternative Names: "Three Prime Repair Exonuclease 2 long form, 3'-5' exonuclease TREX2."

TREX2 is an enzyme that has a 3'-5' exonuclease activity. It removes nucleotides that are mismatched, modified, fragmented, or normal, in order to create the correct 3'-termini for subsequent steps in DNA metabolic pathways. TREX2 is involved in the processes of DNA replication, repair, and recombination.

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  • Sku: PSB-enz-095-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Three Prime Repair Exonuclease 2 (TREX2) is an enzyme that plays a vital role in DNA repair mechanisms. Belonging to the exonuclease family, TREX2 is responsible for the degradation of single-stranded DNA fragments in the 3' to 5' direction. With a molecular weight of approximately X kDa, this enzyme is involved in maintaining genome stability by eliminating aberrant DNA structures and facilitating the repair of damaged DNA. Its significance lies in its ability to contribute to the overall integrity of the DNA molecule, making it an important player in cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The TREX2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 5mM DTT and 30% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSEAPRAETF VFLDLEATGL PSVEPEIAEL SLFAVHRSSL ENPEHDESGA LVLPRVLDKL TLCMCPERPF TAKASEITGL SSEGLARCRK AGFDGAVVRT LQAFLSRQAG PICLVAHNGF DYDFPLLCAE LRRLGARLPR DTVCLDTLPA LRGLDRAHSH GTRARGRQGY SLGSLFHRYF RAEPSAAHSA EGDVHTLLLI FLHRAAELLA WADEQARGWA HIEPMYLPPD DPSLEA

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TREX2

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