TPO

Alternative Names: Thyroid peroxidase, TPO, TPX, MSA, EC 1.11.1.8

Thyroid Peroxidase (TPO) is a crucial autoantigen in autoimmune thyroid disease. TPO, previously known as the `microsomal antigen`, is found in the apical plasma membrane of follicular epithelial cells. Consisting of two subunits with a molecular weight of approximately 100 kDa each, TPO is a hemoprotein responsible for iodination of tyrosyl residues and coupling iodotyrosyl residues in thyroglobulin (TG) to form thyroid hormones T4 and T3.

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  • Sku: PSB-enz-285-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Thyroid Peroxidase is an enzyme that plays a key role in the synthesis of thyroid hormones by catalyzing the oxidation of iodide ions to iodine. Belonging to the peroxidase family, this protein is essential for the production of thyroxine (T4) and triiodothyronine (T3) in the thyroid gland. With a molecular weight of approximately 107 kDa, Recombinant Human Thyroid Peroxidase is a crucial component in the regulation of thyroid function and metabolism.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation TPO is supplied in 16mM HEPES pH-7.6, 160mM NaCl, 0.08mM Kl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TPO

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