TPA (311-562)

Alternative Names: Tissue-type plasminogen activator, tPA, t-PA, t-plasminogen activator, TPA, T-PA, PLAT, EC 3.4.21.68, DKFZp686I03148

Tissue plasminogen activator (tPA) is an enzyme that converts plasminogen into plasmin, which is important for breaking down blood clots. tPA is involved in processes like cell movement and tissue restructuring. Changes in tPA activity can cause excessive bleeding or blood clot formation.

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  • Sku: PSB-enz-1023-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Tissue Plasminogen Activator (311-562 a.a.) is a protein belonging to the serine protease family. This enzyme plays a key role in the breakdown of blood clots by converting plasminogen into plasmin. With a molecular weight of approximately 55 kDa, Recombinant Human Tissue Plasminogen Activator is commonly used in clinical settings for the treatment of conditions such as ischemic stroke and acute myocardial infarction. Its ability to dissolve blood clots makes it a valuable tool in managing thrombotic disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
29.2 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation TPA protein solution (0.5mg/ml) contains 50mM MES (pH 5.0), 5mM CaCl2, 1mM DTT, 0.5M NaCl and 30% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPIKGGLFA DIASHPWQAA IFAKHRRSPG ERFLCGGILI SSCWILSAAH CFQERFPPHH LTVILGRTYR VVPGEEEQKF EVEKYIVHKE FDDDTYDNDI ALLQLKSDSS RCAQESSVVR TVCLPPADLQ LPDWTECELS GYGKHEALSP FYSERLKEAH VRLYPSSRCT SQHLLNRTVT DNMLCAGDTR SGGPQANLHD ACQGDSGGPL VCLNDGRMTL VGIISWGLGC GQKDVPGVYT KVTNYLDWIR DNMRPHHHHH H.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TPA (311-562)

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