TP53I3

Alternative Names: TP53I3, PIG3, Quinone Oxidoreductase, tumor protein p53 inducible protein 3.

TP53I3 contributes to the production of reactive oxygen species (ROS). It has limited activity as an NADPH-dependent naphtoquinone reductase, favoring 1,2-naphtoquinone over 1,4-naphtoquinone. It also has limited activity as an NADPH-dependent diamine reductase (in a laboratory setting). TP53I3 is found in the cytoplasm and is induced in both normal and transformed cell cultures upon exposure to genotoxic substances. A microsatellite polymorphism in TP53I3 is linked to varying susceptibility to cancer.

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  • Sku: PSB-enz-519 -5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Tumor Protein p53 Inducible Protein 3, also known as TP53I3, is a protein that belongs to the p53-inducible gene family. This protein plays a role in regulating cell growth and apoptosis, making it a significant factor in tumor development and progression. With a molecular weight of approximately X kDa, TP53I3 is involved in various cellular processes, including DNA repair and maintenance of genomic stability. Understanding the functions and mechanisms of TP53I3 can provide valuable insights into cancer biology and potentially contribute to the development of targeted therapies.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation 1mg/ml solution containing 20mM Tris HCl pH-8, 0.1M NaCl & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MLAVHFDKPG GPENLYVKEV AKPSPGEGEV LLKVAASALN RADLMQRQGQ YDPPPGASNI LGLEASGHVAELGPGCQGHW KIGDTAMALL PGGGQAQYVT VPEGLLMPIP EGLTLTQAAA IPEAWLTAFQ LLHLVGNVQA GDYVLIHAGL SGVGTAAIQLTRMAGAIPLV TAGSQKKLQM AEKLGAAAGF NYKKEDFSEA TLKFTKGAGV NLILDCIGGS YWEKNVNCLA LDGRWVLYGL MGGGDINGPLFSKLLFKRGS LITSLLRSRD NKYKQMLVNA FTEQILPHFS TEGPQRLLPV LDRIYPVTEI QEAHKYMEAN KNIGKIVLEL PQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TP53I3

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