TECK His

Alternative Names: Thymus-expressed chemokine, C-C motif chemokine 25, Small-inducible cytokine A25, Chemokine TECK, CCL25, SCYA25, TECK, Ckb15, MGC150327.

CCL25 (Teck) is a newly discovered CC chemokine that shares about 20% amino acid sequence identity with other CC chemokines. It has been found to be predominantly expressed in the thymus and small intestine in both humans and mice. Dendritic cells in the thymus are responsible for producing CCL25, while those derived from bone marrow do not produce it. CCL25 signals through the CCR9 receptor and may play a role in T-cell development. Recombinant human and mouse Teck have been shown to attract activated macrophages, dendritic cells, and thymocytes. However, they do not have the same effect on peripheral blood lymphocytes and neutrophils.

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  • Sku: PSB-chm-032-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Thymus Expressed Chemokine (CCL25), His Tag is a protein belonging to the chemokine family. It plays a role in immune cell chemotaxis and inflammation regulation. With a molecular weight of approximately 9.3 kDa, this protein is commonly used in research and therapeutic applications for its chemotactic properties. The addition of a His Tag allows for easy purification and detection in experimental settings.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
16.8 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation TECK protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMQGVFE DCCLAYHYPI GWAVLRRAWT YRIQEVSGSC NLPAAIFYLP KRHRKVCGNP KSREVQRAMK LLDARNKVFA KLHHNTQTFQ AGPHAVKKLS SGNSKLSSSK FSNPISSSKR NVSLLISANS GL.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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TECK His

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