SOST, HEK

Alternative Names: Sclerostin, SOST, CDD, VBCH

Sclerostin (SOST) is a glycoprotein that regulates bone growth by inhibiting bone formation. It has a C-terminal cysteine knot-like (CTCK) domain and is similar to the DAN family of bone morphogenetic protein (BMP) antagonists. SOST is expressed at low levels in various tissues, with the highest levels found in the bone, cartilage, kidney, liver, bone marrow, and primary osteoblasts. Mutations in the SOST gene are associated with sclerosteosis and bone dysplasia.

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  • Sku: PSB-pro-2481-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Sclerostin, HEK, is a protein belonging to the family of glycoproteins known as cystine knot-containing secreted proteins. With a molecular weight of approximately 28 kilodaltons, this protein plays a significant role in regulating bone formation by inhibiting the Wnt signaling pathway. Recombinant Human Sclerostin, HEK, is produced through recombinant DNA technology using human embryonic kidney (HEK) cells, ensuring its purity and consistency for research purposes. Its precise mechanism of action and potential therapeutic applications make it a subject of scientific interest in the field of bone biology and related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 95.0 % by SDS-PAGE
Activity
Activity Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
22.4 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation SOST filtered (0.4 µm) and lyophilized from 0.5mg/ml in PBS and 5 % (w/v) trehalose, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

QGWQAFKNDA TEIIPELGEY PEPPPELENN KTMNRAENGG RPPHHPFETK DVSEYSCREL HFTRYVTDGP CRSAKPVTEL VCSGQCGPAR LLPNAIGRGK WWRPSGPDFR CIPDRYRAQR VQLLCPGGEA PRARKVRLVA SCKCKRLTRF HNQSELKDFG TEAARPQKGR KPRPRARSAK ANQAELENAY HHHHHH.

Storage Instruction

Store lyophilized protein at -20° C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4° C for a limited period of time; it does not show any change after one week at 4° C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. SOST is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available

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SOST, HEK

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