SNRPA

Alternative Names: U1 snRNP A, U1-A, U1A, U1 small nuclear ribonucleoprotein A, SNRPA, Mud1.

SNRPA is a protein that interacts with stem loop II of U1 small nuclear ribonucleoprotein. This interaction is crucial for binding to the 5' splice site of precursor mRNAs and plays a key role in splicing. SNRPA is unique as it can autoregulate itself by inhibiting the polyadenylation of its own pre-mRNA through dimerization. Additionally, it is involved in the coordination of splicing and polyadenylation. SNRPA is the first snRNP to interact with pre-mRNA, and this interaction is essential for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP.

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  • Sku: PSB-pro-1509-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA), a member of the small nuclear ribonucleoprotein (snRNP) family, is a protein involved in pre-mRNA splicing. With a molecular weight of approximately X kDa, SNRPA plays a crucial role in the formation of spliceosomes, which are macromolecular complexes responsible for removing introns from pre-mRNA molecules. This recombinant protein is widely used in research and biotechnological applications to study the intricate mechanisms of RNA processing and splicing.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation SNRPA is supplied in 16mM HEPES buffer pH-7.6, 400mM NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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SNRPA

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