SNAP-25

Alternative Names: Super-Protein, SUP, RIC4, SEC9, SNAP, RIC-4, SNAP25, SNAP-25, Synaptosomal-associated protein 25, Synaptosomal-associated 25 kDa protein, FLJ23079, bA416N4.2, dJ1068F16.2.

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) on the vesicle and target membranes mediate the docking and fusion of synaptic vesicle membranes. The v-SNAREs and t-SNAREs form a complex consisting of four helices, with one helix contributed by v-SNARE and the other three by t-SNARE. On the plasma membrane, one helix is supplied by the protein syntaxin and the other two by the protein encoded by this gene. This gene's product, SNAP25, is a plasma membrane protein that plays a role in regulating neurotransmitter release. SNAP-25 is an essential part of the core complex involved in presynaptic vesicle trafficking, directly participating in neurotransmitter release.

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  • Sku: PSB-pro-396-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Synaptosomal-associated protein 25kDa, C.elegans is a protein derived from the nematode Caenorhabditis elegans. Belonging to the synaptosomal-associated protein (SNAP-25) family, it plays a significant role in the regulation of neurotransmitter release and synaptic vesicle fusion. With a molecular weight of approximately 25 kilodaltons, this protein serves as a crucial component in the intricate machinery of synaptic transmission. Its functional significance in synaptic processes makes it a subject of interest in neurological research and drug development targeting neurodegenerative disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 C.elegans
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein contains 20mM Tris-HCl pH7.5, 50mM NaCl, 5mM DTT, 1mM EDTA and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSGDDDIPEG LEAINLKMNA TTDDSLESTR RMLALCEESK EAGIKTLVML DDQGEQLERCEGALDTINQD MKEAEDHLKG MEKCCGLCVL PWNKTDDFEK TEFAKAWKKD DDGGVISDQPRITVGDSSMG PQGGYITKIT NDAREDEMDE NVQQVSTMVG NLRNMAIDMS TEVSNQNRQL DRIHDKAQSN EVRVESANKR AKNLITK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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SNAP-25
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