SDF1a

Alternative Names: CXCL12, chemokine (C-X-C motif) ligand 12, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1, SDF1, SDF1A, SDF-1a, SCYB12, TPAR1, TLSF-a

SDF-1, also known as CXCL12, is a small cytokine in the chemokine family produced in two forms by alternate splicing of the same gene. It is chemotactic for lymphocytes and plays a crucial role in cell migration during development, such as directing hematopoietic cells from fetal liver to bone marrow. Knockout mice for the CXCL12 gene were lethal before or shortly after birth. CXCL12 is expressed in various tissues in mice, including the brain, thymus, heart, and bone marrow. The receptor for this chemokine is CXCR4. The gene for CXCL12 is located on human chromosome 10, with high sequence identity between human and mouse CXCL12 and CXCR4. Recently, it was suggested that CXCR7 may also bind CXCL12.

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  • Sku: PSB-chm-262-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Stromal Cell-Derived Factor-1 alpha (CXCL12) is a chemokine protein that belongs to the CXC chemokine family. It plays a significant role in immune responses and inflammation by attracting immune cells to sites of injury or infection. CXCL12 has a molecular weight of approximately 8 kDa and is involved in various physiological processes, including hematopoiesis, angiogenesis, and tissue repair. This recombinant protein is commonly used in research and therapeutic applications for its chemotactic properties.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The specific activity as determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml corresponding to a Specific Activity of 12,500-50,000IU/mg. The specific activity as determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml corresponding to a Specific Activity of 12,500-50,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK

Storage Instruction

Lyophilized SDF-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL12 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Stromal Cell-Derived Factor-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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SDF1a
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