SDF 1g

Alternative Names: Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, CXCL12, SDF1, hSDF-1gamma, SDF-1g, Pre-B cell growth-stimulating factor, PBSF, Intercrine reduced in hepatomas, IRH, hIRH, TLSF, TPAR1, SCYB12.

SDF-1, also known as CXCL12, is a small cytokine from the chemokine family that plays a crucial role in cell coordination during development. It is produced in two forms, SDF-1a/CXCL12a and SDF-1b/CXCL12b, by alternate splicing of the same gene. CXCL12 is highly chemotactic for lymphocytes and directs the migration of hematopoietic cells during embryogenesis. Knock-out mice for the CXCL12 gene were found to be lethal, indicating its importance for survival. CXCL12 is expressed in various tissues in mice, including the brain, thymus, heart, and bone marrow. The receptor for CXCL12 is CXCR4, and recent studies suggest that CXCR7 may also interact with CXCL12. The gene for CXCL12 is located on human chromosome 10, and both human and mouse versions of CXCL12 and CXCR4 show high sequence identity.

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  • Sku: PSB-chm-020-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Stromal Cell-Derived Factor-1 gamma (CXCL12) is a chemokine protein belonging to the CXC chemokine family. It plays a critical role in immune response and cell migration by binding to its receptor, CXCR4. With a molecular weight of approximately 8 kDa, CXCL12 is involved in various physiological processes, including hematopoiesis, angiogenesis, and tissue repair. Its recombinant form is commonly used in research and therapeutic applications to study its functions and potential therapeutic benefits.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 96.0% by SDS-PAGE
Activity
 The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 30-100 ng/ml. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 30-100 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 11.6 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation SDF-1g protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN.

Storage Instruction

Lyophilized SDF-1g although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SDF-1 gamma should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized SDF-1g in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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SDF 1g
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