SCF

Alternative Names: C-kit ligand, Kit ligand Precursor, SCF, Mast cell growth factor, MGF, SF, KL-1, Kitl, DKFZp686F2250.

Stem cell factor (SCF), also known as c-kit ligand, is a cytokine that binds CD117. SCF exists in two forms: cell surface bound SCF and soluble SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases. SCF plays a key role in the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its functions is to convert BFU-E cells into CFU-E cells, which are early erythrocyte precursors in the erythrocytic series.

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  • Sku: PSB-cyt-255-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Stem Cell Factor, a member of the hematopoietic growth factor family, is a protein that plays a crucial role in the regulation of hematopoiesis. With a molecular weight of approximately 18.4 kDa, this protein is involved in the proliferation, differentiation, and survival of hematopoietic stem cells. Recombinant Human Stem Cell Factor is commonly used in research and clinical applications to support the expansion and maintenance of stem cells in vitro. Its ability to stimulate the growth of various blood cell types makes it a valuable tool in the field of regenerative medicine.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The ED50 as determined by the dose-dependant stimulation of Human TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 500,000 IU/mg. The ED50 as determined by the dose-dependant stimulation of Human TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 500,000 IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing 0.02% NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Gly-Ile-Cys.

Storage Instruction

Lyophilized KIT ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SCF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Stem Cell Factor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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SCF
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