SAR1B

Alternative Names: CMRD, ANDD, GTBPB, GTP-binding protein B, GTP-binding protein SAR1b, SAR1B, SARA2, SARB

SAR1B is a small GTPase that functions as a homodimer in the transport process from the endoplasmic reticulum to the Golgi apparatus. It is responsible for selecting protein cargo and assembling the COPII coat complex. Activation of SAR1B is facilitated by the guanine nucleotide exchange factor PREB. Defects in the SAR1B gene are known to cause chylomicron retention disease, also referred to as Anderson disease.

  •
  • Sku: PSB-pro-310-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human GTP-Binding Protein SAR1B is a protein involved in vesicle trafficking and protein transport within cells. Belonging to the GTP-binding protein family, SAR1B plays a crucial role in the formation of COPII-coated transport vesicles. With a molecular weight of approximately 25 kilodaltons, this protein regulates the export of cargo from the endoplasmic reticulum to the Golgi apparatus. Its GTPase activity facilitates the assembly and disassembly of the COPII coat, ensuring efficient protein sorting and secretion. Understanding the function and regulation of SAR1B is of great significance in elucidating cellular transport mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.8 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation SAR1B protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSFIFDW IYSGFSSVLQ FLGLYKKTGK LVFLGLDNAG KTTLLHMLKD DRLGQHVPTL HPTSEELTIA GMTFTTFDLG GHVQARRVWK NYLPAINGIV FLVDCADHER LLESKEELDS LMTDETIANV PILILGNKID RPEAISEERL REMFGLYGQT TGKGSISLKE LNARPLEVFM CSVLKRQGYG EGFRWMAQYI D.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
View full details

SAR1B
SUBHEADING

Recently viewed products