SAP18

Alternative Names: Histone deacetylase complex subunit SAP18, Sin3-associated polypeptide 18 kDa, Sin3-associated polypeptide p18, Cell growth-inhibiting protein 38, 2HOR0202, GIG38, SAP18.

SAP18 is a key member of the histone deacetylase complex, which plays a crucial role in regulating gene expression in eukaryotes. It interacts directly with SIN3, enhancing SIN3's ability to repress gene transcription. SAP18 is also important for recruiting the HDAC complex to specific genes through various transcription factors such as Gli, GAGA, and Bicoid. Histone acetylation is a significant process in gene regulation, and SAP18 is part of a larger complex that catalyzes both acetylation and deacetylation of histones. Additionally, SAP18 is also involved in the splicing-dependent EJC complex that is placed at splice junctions on mRNAs.

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  • Sku: PSB-pro-707-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human Sin3A-Associated Protein, 18kDa, is a protein that plays a significant role in gene regulation and transcriptional repression. Belonging to the Sin3 family of proteins, it functions as a core component of the Sin3 histone deacetylase complex. With a molecular weight of 18 kilodaltons, this protein is involved in the recruitment of histone deacetylases to target genes, leading to the repression of transcription and subsequent control of various cellular processes. Its precise functions and interactions make Recombinant Human Sin3A-Associated Protein, 18kDa, a valuable tool for studying gene expression and chromatin remodeling mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The SAP18 solution contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 30% glycerol, 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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SAP18
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