SAE1/SAE2

Alternative Names: Not Available

SAE1 and SAE2 heterodimers are involved in the posttranslational modification of proteins through sumoylation process. This process regulates protein structure and intracellular localization of target proteins. Interestingly, autoantibodies against SAE1/SAE2 have been detected in patients with dermatomyositis (DM), suggesting their potential role as markers for this condition.

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  • Sku: PSB-enz-1161-50µg
  • Vendor: ProSpec-Tany
$600.00 USD
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Title

Product Details

Product Description

Recombinant Human SAE1/SAE2 is a protein complex belonging to the Small Ubiquitin-like Modifier (SUMO) family. With a molecular weight of approximately X kDa, it plays a significant role in the post-translational modification process known as SUMOylation. This complex facilitates the covalent attachment of SUMO proteins to target proteins, thereby regulating various cellular processes. The Recombinant Human SAE1/SAE2 protein complex is widely studied for its involvement in protein-protein interactions and its potential implications in disease mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation SAE1/SAE2 is supplied in 20mM HEPES buffer pH-8.0, 200mM NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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SAE1/SAE2

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