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S100A8, His-Myc

Alternative Names: S100 Calcium Binding Protein A8, S100 Calcium-Binding Protein A8 (Calgranulin A), Migration Inhibitory Factor-Related Protein 8, Leukocyte L1 Complex Light Chain, Urinary Stone Protein Band A, Calprotectin L1L Subunit, Cystic Fibrosis Antigen, Calgranulin-A, MRP8, CAGA, CFAG, P8, S100 Calcium Binding Protein A8 (Calgranulin A), S100 Calcium-Binding Protein A8, Calgranulin A, 60B8AG, CP-10, MA38, MRP-8, CGLA, L1Ag, MIF, NIF.

S100A8 is a calcium-binding protein belonging to the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs. These proteins are found in the cytoplasm and/or nucleus of various cells and are involved in regulating cellular processes such as cell cycle progression and differentiation. S100A8 has been shown to inhibit casein kinase and act as a cytokine. Its expression has been found to be altered in cystic fibrosis disease. Moreover, S100A8 exhibits antimicrobial activity against bacteria and fungi, making it essential for defense against pathogenic bacteria. It also up-regulates the transcription of genes controlled by NF-kappa-B and contributes to the development of endotoxic shock in response to bacterial lipopolysaccharide. Additionally, S100A8 promotes tubulin polymerization and facilitates migration of phagocytes and infiltration of granulocytes at wound sites. It acts as a pro-inflammatory mediator in both acute and chronic inflammation and up-regulates the release of IL8 and the cell-surface expression of ICAM1.

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  • Sku: PSB-pro-2329-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Product Details

Product Description

Recombinant Human S100 Calcium Binding Protein A8, His-Myc Tag is a genetically engineered protein that contains a histidine-myc epitope tag for easy detection and purification purposes. Belonging to the S100 protein family, this protein is involved in calcium binding and plays a role in regulating various cellular processes. With a molecular weight of approximately [insert weight], it is extensively studied in the field of cell biology and has been implicated in several pathological conditions. This recombinant protein is commonly utilized in research settings to investigate its functional properties and molecular interactions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 14.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The S100A8 solution (1mg/ml) contains 20mM Tris-HCl (pH 8.0), 10% glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMLTELE KALNSIIDVY HKYSLIKGNF HAVYRDDLKK LLETECPQYI RKKGADVWFK ELDINTDGAV NFQEFLILVI KMGVAAHKKS HEESHKEEQK LISEEDL.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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