S100A8

Alternative Names: Calgranulin A, MRP8, CAGA, CGLA, CFAG, Protein S100-A8, S100 calcium-binding protein A8, Migration inhibitory factor-related protein 8, MRP-8, p8, Cystic fibrosis antigen, Leukocyte L1 complex light chain, Calprotectin L1L subunit, Urinary stone protein band A, S100A8, MIF, NIF, L1Ag, CP-10, MA387, 60B8AG.

S100A8 is a member of the S100 protein family, which contains 2 EF-hand calcium-binding motifs. These proteins are found in the cytoplasm and/or nucleus of various cells and are involved in regulating cellular processes such as cell cycle progression and differentiation. S100A8 serves as an inhibitor of casein kinase and functions as a cytokine. Altered expression of S100A8 is associated with cystic fibrosis. It acts as a calcium-binding protein with antimicrobial activity against bacteria and fungi. S100A8 is critical for defending against invasion by pathogenic bacteria. It enhances the transcription of genes regulated by NF-kappa-B and contributes to the development of endotoxic shock caused by bacterial lipopolysaccharide. Additionally, S100A8 promotes tubulin polymerization and facilitates the migration and infiltration of immune cells at wound sites. It acts as a pro-inflammatory mediator in both acute and chronic inflammation, increasing the release of IL8 and the expression of ICAM1 on the cell surface.

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  • Sku: PSB-pro-800-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human S100 Calcium Binding Protein A8, also known as S100A8, is a member of the S100 protein family. This protein plays a significant role in various cellular processes, including inflammation, immune response, and calcium signaling. With a molecular weight of approximately 10.8 kDa, S100A8 is involved in the regulation of cell proliferation, differentiation, and migration. It acts as a damage-associated molecular pattern molecule, contributing to the pathogenesis of several inflammatory and autoimmune diseases. The recombinant form of this protein is widely used in research and diagnostic applications to investigate its function and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The S100A8 solution (0.5mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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S100A8
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