RXRA

Alternative Names: RXRA, RXR Alpha, RXR-a, Retinoic acid receptor RXR-alpha, Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1, NR2B1, FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720.

The retinoid X receptor (RXR) is a nuclear receptor transcription factor that interacts with other nuclear receptors. It binds to specific response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily. This includes retinoic acid receptors, thyroid hormone receptors, vitamin D receptors, and peroxisome proliferators-activated receptors. The RXR family includes three isoforms: RXR a, b, and g. The human RXR a gene is located on 9q34.9 and produces two major isoforms (RXR a1 and RXR a2). The DNA binding domain of RXR (111-228 amino acids) was isolated using column chromatography methods.

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  • Sku: PSB-pro-437-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Retinoid X Receptor Alpha is a protein that belongs to the nuclear receptor family, specifically the retinoid X receptor subfamily. With a molecular weight of approximately [insert weight], this receptor plays a significant role in regulating gene expression by forming heterodimers with other nuclear receptors. It acts as a transcription factor, binding to specific DNA sequences and modulating the transcription of target genes involved in various biological processes. The Recombinant Human Retinoid X Receptor Alpha is widely studied for its involvement in cellular differentiation, embryonic development, and metabolism.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein (1mg/ml) containing 20mM Tris-HCl pH7.5, 0.1M NaCl and 5mM ?-Mercaptoethanol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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RXRA
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