RUNX3

Alternative Names: AML2, Oncogene AML-2, Acute myeloid leukemia 2 protein, CBFA3, Core-binding factor subunit alpha-3, RUNX3, Runt-related transcription factor 3, PEBP2aC, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEBP2A3, SL3/AKV core-binding factor alpha C subunit, SL3-3 enhancer factor 1 alpha C subunit, FLJ34510, MGC16070.

RUNX3, a member of the RUNX family, plays a role in regulating the expression of genes involved in cellular differentiation and cell cycle progression. It forms a complex with the beta subunit to bind to a specific DNA sequence found in enhancers and promoters, thereby controlling transcription activation or suppression. RUNX3 also interacts with other transcription factors, making it a potential candidate for diagnosing gastric cancer as a tumor suppressor.

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  • Sku: PSB-pro-836-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Runt-Related Transcription Factor 3 (RUNX3) is a protein that belongs to the Runt family of transcription factors. With a molecular weight of approximately 45 kilodaltons (kDa), RUNX3 plays a significant role in regulating gene expression and cell differentiation processes. As a member of the Runt family, RUNX3 is involved in various developmental and physiological processes, including embryogenesis, hematopoiesis, and osteogenesis. Its importance lies in its ability to bind to specific DNA sequences and modulate the transcription of target genes, thereby influencing cellular functions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation RUNX3 Human solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MRSMVDVLAD HAGELVRTDS PNFLCSVLPS HWRCNKTLPV AFKVVALGDV PDGTVVTVMA GNDENYSAEL RNASAVMKNQ VARFNDLRFV GRSGRGKSFT LTITVFTNPT QVATYHRAIK VTVDGPREPR RHRQK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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RUNX3
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