RSPO3

Alternative Names: CRISTIN1, hPWTSR, hRspo3, PWTSR, R-spondin-3, Roof plate-specific spondin-3, Protein with TSP type-1 repeat, RSPO3, Thrombospondin type-1 domain-containing protein 2, THSD2, THSD2.

RSPO3, a secreted protein, belongs to the thrombospondin type 1 repeat supergene family. It is widely expressed in various tissues. RSPO3 contains 2 Furin-like repeats and one TSP type-1 domain. It plays a role as an activator of the beta-catenin signaling cascade, which leads to TCF-dependent gene activation.

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  • Sku: PSB-pro-1646-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human R-Spondin-3 is a protein belonging to the R-Spondin family, which plays a significant role in embryonic development and tissue homeostasis. This protein, with a molecular weight of approximately 35 kDa, acts as a potent agonist of the Wnt signaling pathway, thereby regulating stem cell proliferation and differentiation. By binding to the LGR4-6 receptors, R-Spondin-3 enhances Wnt signaling, ultimately contributing to tissue regeneration and maintenance. Its therapeutic potential lies in its ability to promote tissue repair and regeneration in various pathological conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation RSPO3 was lyophilized from a 0.2µm filtered solution in 20mM PB, and 150mM NaCl pH-7.2.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

QNASRGRRQR RMHPNVSQGC QGGCATCSDY NGCLSCKPRL FFALERIGMK QIGVCLSSCP SGYYGTRYPD INKCTKCKAD CDTCFNKNFC TKCKSGFYLH LGKCLDNCPE GLEANNHTME CVSIVHCEVS EWNPWSPCTK KGKTCGFKRG TETRVREIIQ HPSAKGNLCP PTNETRKCTV DDIEGRMDEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH.

Storage Instruction

Lyophilized RSPO3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution RSPO3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to quick spin followed by reconstitution of RSPO3 in PBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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RSPO3

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