RSPO1

Alternative Names: Roof plate-specific spondin-1, Rspo1, RSPO, R-spondin 1, R-spondin, Rspondin, CRISTIN3, R-spondin-1, Cristin-3, mCristin-3.

R-Spondin-1 (Rspo1) is a member of the Rspondin family and functions as an activator of the canonical Wnt signaling pathway. It acts as a ligand for LGR4-6 receptors, stimulating the proliferation of crypt cells and promoting the healing of the intestinal epithelium. Notably, Rspo1 also plays a role in negatively regulating the TGF-beta pathway.

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  • Sku: PSB-pro-2593-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human R-Spondin-1 is a protein that belongs to the R-Spondin family, which plays a significant role in regulating cell proliferation and differentiation in various tissues. With a molecular weight of approximately X kDa, this protein acts as a potent agonist of the Wnt signaling pathway, thereby enhancing stem cell self-renewal and promoting tissue regeneration. Its therapeutic potential lies in its ability to stimulate tissue repair and regeneration, making it a promising candidate for various medical applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System CHO
Purity 95.0 % by SDS-PAGE
Activity
The ED50, as calculated by the Luciferase induction in HEK-293 STF cells in the presence of Murine Wnt-3a is 47.99ng/ml corresponding to a specific activity of 2.1 x 10^4 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
25.6 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein was lyophilized from a sterile (0.2µm) filtered solution containing PBS.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized RSPO1in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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RSPO1

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