rSDF1a

Alternative Names: CXCL12, chemokine (C-X-C motif) ligand 12, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1, SDF1, SDF1A, SDF-1a, SCYB12, TPAR1, Thymic lymphoma cell-stimulating factor, TLSF, TLSF-a, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1.

SDF-1, a small cytokine belonging to the chemokine family, is produced in two forms - SDF-1?/CXCL12a and SDF-1?/CXCL12b - through alternate splicing of the same gene. It is known for its role in directing the migration of hematopoietic cells during embryogenesis. Knock-out mice for the CXCL12 gene were found to be lethal before birth or shortly after. CXCL12 has been shown to be expressed in various tissues in mice. The receptor for CXCL12 is CXCR4, although recent studies suggest it may also bind to the CXCR7 receptor. The gene for CXCL12 is located on human chromosome 10, and both human and mouse versions of CXCL12 and CXCR4 share high sequence identities.

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  • Sku: PSB-chm-354-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Stromal Cell-Derived Factor-1 alpha (CXCL12) is a chemokine belonging to the CXC subfamily. With a molecular weight of approximately 8 kDa, CXCL12 plays a significant role in cell migration and recruitment, particularly in the context of hematopoiesis and immune responses. This recombinant protein is commonly used in research settings to study its effects on various cellular processes and its potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The specific activity as determined by its ability to chemoattract human peripheral blood monocytes at 50-100ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg. The specific activity as determined by its ability to chemoattract human peripheral blood monocytes at 50-100ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The CXCL12 protein was lyophilized from a concentrated (1 mg/ml) sterile solution containing 20mM Phosphate buffer pH-7.4 and 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK.

Storage Instruction

Lyophilized SDF-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL12 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized SDF-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rSDF1a
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