RPRD1A

Alternative Names: Regulation of Nuclear Pre-MRNA Domain Containing 1A, Regulation of Nuclear Pre-MRNA Domain-Containing Protein 1A, RPRD1A, P15RS, Cyclin-Dependent Kinase Inhibitor 2B-Related Protein, Cyclin-Dependent Kinase 2B-Inhibitor-Related Protein, Cyclin-Dependent Kinase Inhibitor 2B-Related Protein (P15INK4B-Related Protein), P15INK4B-Related Protein, HsT3101, FLJ10656.

RPRD1A is a regulatory protein that becomes more active in cells that produce an excess of cyclin-dependent kinase inhibitor p15(INK4b). Its presence is believed to play a role in controlling the cell cycle. RPRD1A interacts with a phosphorylated domain at the end of the POLR2A protein, which is the largest subunit of RNA polymerase II. This interaction contributes to the removal of phosphate groups from the POLR2A protein. RPRD1A has also been observed to potentially inhibit the expression of cyclin-D1 (CCND1) and cyclin-E (CCNE1) during the cell cycle.

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  • Sku: PSB-pro-1945-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Regulation Of Nuclear Pre-MRNA Domain Containing 1A (RPRD1A) is a protein that belongs to the RPRD1 family. With a molecular weight of approximately X kDa, RPRD1A plays a significant role in the regulation of nuclear pre-mRNA processing. This protein is involved in various cellular processes, including transcriptional regulation and mRNA splicing. Understanding the functions and mechanisms of RPRD1A can provide valuable insights into gene expression and RNA processing pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The RPRD1A solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSEFMSAFS EAALEKKLSE LSNSQQSVQT LSLWLIHHRK HSRPIVTVWE RELRKAKPNR KLTFLYLAND VIQNSKRKGP EFTKDFAPVI VEAFKHVSSE TDESCKKHLG RVLSIWEERS VYENDVLEQL KQALYGDKKP RKRTYEQIKV DENENCSSLG SPSEPPQTLD LVRALQDLEN AASGDAAVHQ RIASLPVEVQ EVSLLDKITD KESGERLSKM VEDACMLLAD YNGRLAAEID DRKQLTRMLA DFLRCQKEAL AEKEHKLEEY KRKLARVSLV RKELRSRIQS LPDLSRLPNV TGSHMHLPFA GDIYSED.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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RPRD1A
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