RNF7

Alternative Names: Ring finger protein 7, RING-box protein 2, Rbx2, Regulator of cullins 2, ROC2, RNF7, CKBBP1, CKII beta-binding protein 1, Sensitive to apoptosis gene protein, SAG, RBX2, RING-box protein 2 isoform 1.

Ring Finger Protein 7, or RNF7, is a highly conserved ring finger protein. It plays a crucial role as a subunit of the SKP1-cullin/CDC53-F box protein ubiquitin ligases. These ligases are involved in the degradation of proteins, which is important for cell cycle progression and signal transduction. RNF7 itself can be phosphorylated by casein kinase II (CSNK2A1/CKII), which promotes the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1 (CDKN1B).

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  • Sku: PSB-pro-1671-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Ring Finger Protein 7 (RNF7) is a member of the Ring finger protein family, characterized by the presence of a conserved zinc-binding domain known as the Ring finger domain. RNF7 plays a role in protein degradation and cellular homeostasis through its involvement in the ubiquitin-proteasome system. With a molecular weight of approximately X kDa, RNF7 functions as an E3 ubiquitin ligase, facilitating the transfer of ubiquitin molecules onto target proteins for subsequent degradation. Its precise regulatory mechanisms and physiological significance are areas of ongoing research in the field of molecular biology.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 15.1 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation RNF7 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMADVEDG EETCALASHS GSSGSKSGGD KMFSLKKWNA VAMWSWDVEC DTCAICRVQV MDACLRCQAE NKQEDCVVVW GECNHSFHNC CMSLWVKQNN RCPLCQQDWV VQRIGK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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RNF7
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