rMIP 1b

Alternative Names: C-C motif chemokine 4, Ccl4, Macrophage inflammatory protein 1-beta, MIP-1-beta, Mip1b, Small-inducible cytokine A4, Scya4.

Macrophage Inflammatory Proteins (MIP) are chemotactic cytokines belonging to the chemokine family. In humans, these proteins are officially named CCL3 and CCL4, previously known as MIP-1? and MIP-1?. These proteins are produced by macrophages in response to bacterial endotoxins and activate human granulocytes, leading to acute neutrophilic inflammation. They also stimulate the production of other pro-inflammatory cytokines such as IL-1, IL-6 and TNF-? from fibroblasts and macrophages. The genes for CCL3 and CCL4 are located on human chromosome 17.

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  • Sku: PSB-chm-003-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Macrophage Inflammatory protein-1 beta (CCL4) is a chemokine belonging to the CC subfamily. This protein plays a role in the immune response by attracting and activating macrophages and other immune cells to sites of inflammation. With a molecular weight of approximately 8.6 kDa, CCL4 is involved in the regulation of inflammatory processes and immune cell migration. Its recombinant form is commonly used in research settings to study immune responses and inflammatory diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml. Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Filtered (0.2µm) and lyophilized from a concentrated (1mg/ml) solution in 30% Acetonitrile and 0.1% TFA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN.

Storage Instruction

Lyophilized Mouse MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rMIP 1b
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