rMEC

Alternative Names: CCK1, Protein CCK1, MEC, MGC71902, SCYA28, Small-inducible cytokine A28, CCL28, C-C motif chemokine 28, Mucosae-associated epithelial chemokine.

CCL28 is a small cytokine CC gene that acts as a chemoattractant for certain immune cells and binds to specific chemokine receptors. It plays a role in the function of various mucosal tissues and is important in mucosal immunity, particularly in HIV exposure and infection, as well as in the development of inflammatory skin diseases. The human CCL28 gene encodes a precursor protein that is cleaved to produce a mature protein. It shares a high degree of amino acid identity with mouse CCL28 and has similarities to CCL27/CTACK. Expression of CCL28 occurs predominantly in normal and pathologic colon tissue and in epithelial cells, with some presence in normal and asthmatic lung tissues as well.

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  • Sku: PSB-chm-278-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Mucosae-Associated Epithelial Chemokine (CCL28) is a chemokine protein belonging to the CC chemokine family. With a molecular weight of approximately 12 kDa, CCL28 plays a role in the recruitment of immune cells to mucosal tissues. This chemokine is involved in the regulation of inflammatory responses and immune cell trafficking, particularly in the mucosal epithelium. Its expression is induced in response to various stimuli, contributing to the maintenance of mucosal homeostasis and immune defense mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml. Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 13.1 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4 and150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SEAILPIASS CCTEVSHHIP RRLLERVNSC SIQRADGDCD LAAVILHVKR RRICVSPHNP TLKRWMSASE MKNGKENLCP RKKQDSGKDR KGHTPRKHGK HGTRRIHGTH DHEAPR.

Storage Instruction

Lyophilized MEC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution MEC should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized MEC in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rMEC
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