RLN3

Alternative Names: RLN3, Relaxin-3, Relaxin 3, Relaxin 3 (H3), Prorelaxin H3, RXN3, H3, Insl7, ZINS4

Relaxin-3 (RLN3) is a member of the relaxin family, which includes endocrine and autocrine/paracrine hormones. Unlike other relaxins, RLN3 does not play a role in reproduction but is involved in the stress response in the brain stem. RLN3 binds to two receptors, GPCR135 (RXFP3) and LGR7 (RXFP1), with higher affinity for LGR7. Binding of RLN3 to LGR7 increases intracellular cAMP, while binding to GPCR135 suppresses cAMP accumulation, suggesting coupling to Gi, Go, or Gz by this receptor.

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  • Sku: PSB-pro-2176-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Relaxin-3 is a protein that belongs to the relaxin family. With a molecular weight of approximately X kDa, it plays a significant role in various physiological processes. This protein is involved in the regulation of stress response, appetite, and arousal, among other functions. Recombinant Human Relaxin-3 is synthesized through genetic engineering techniques, allowing for its production in large quantities for research purposes. Its precise mechanism of action and potential therapeutic applications are currently under investigation.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
The ED50, as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from a 0.2µm filtered solution in Acetonitrile and TFA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

A chain: DVLAGLSSSC CKWGCSKSEI SSLC - B chain: RAAPYGVRLCG REFIRAVIFT CGGSRW

Storage Instruction

Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Relaxin-3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized RLN3 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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RLN3

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