RLBP1

Alternative Names: Cellular Retinaldehyde-Binding Protein, CRALBP, Retinaldehyde Binding Protein 1.

RLBP1, a 36-kD water-soluble protein, functions as a transporter for 11-cis-retinal or 11-cis-retinaldehyde, which are important ligands in the visual cycle. Mutations in the RLBP1 gene are linked to retinitis punctata albescens, severe rod-cone dystrophy, and Bothnia dystrophy. These conditions are forms of nonsyndromic autosomal recessive retinitis pigmentosa.

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  • Sku: PSB-pro-1845-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Retinaldehyde Binding Protein 1 (RLBP1) is a protein that belongs to the fatty acid-binding protein (FABP) family. With a molecular weight of approximately 15 kDa, RLBP1 plays a significant role in the transport and storage of retinoids, which are essential for vision and cellular differentiation. As a member of the FABP family, RLBP1 exhibits high affinity for retinoids, facilitating their efficient uptake and delivery to target tissues. Its precise binding and transport mechanisms make RLBP1 a crucial player in maintaining retinoid homeostasis within the visual system.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The RLBP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSEGVGT FRMVPEEEQE LRAQLEQLTT KDHGPVFGPC SQLPRHTLQK AKDELNEREE TREEAVRELQ EMVQAQAASG EELAVAVAER VQEKDSGFFL RFIRARKFNV GRAYELLRGY VNFRLQYPEL FDSLSPEAVR CTIEAGYPGV LSSRDKYGRV VMLFNIENWQ SQEITFDEIL QAYCFILEKL LENEETQING FCIIENFKGF TMQQAASLRT SDLRKMVDML QDSFPARFKA IHFIHQPWYF TTTYNVVKPF LKSKLLERVF VHGDDLSGFY QEIDENILPS DFGGTLPKYD GKAVAEQLFG PQAQAENTAF

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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RLBP1

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