rIL1RA

Alternative Names: IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, IRAP, MGC10430.

Interleukin-1 ra is a cytokine that belongs to the interleukin 1 family. It inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and affects various immune and inflammatory responses related to interleukin 1. This gene, along with five other closely related cytokine genes, forms a gene cluster that spans about 400 kb on chromosome 2. A genetic variation of this gene is associated with an increased risk of osteoporotic fractures and gastric cancer. Four different versions of the gene, known as transcript variants, have been identified.

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  • Sku: PSB-cyt-152-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Interleukin-1 Receptor Antagonist, a member of the interleukin-1 receptor antagonist (IL-1RA) family, is a protein with a molecular weight of approximately X kDa. It functions by competitively binding to the IL-1 receptor, thereby inhibiting the biological activities of interleukin-1 (IL-1). This recombinant protein plays a significant role in regulating immune responses and inflammatory processes. Its precise molecular structure and mechanism of action make it a valuable tool for studying the intricate pathways involved in immune system modulation and inflammation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Fully biologically active when compared to standard. Measured by its ability to inhibit IL1a-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 30-150ng/ml (corresponding to a specific activity of 6,667-33,334units/mg ) in the presence of 50pg/ml of rrIL1a. Fully biologically active when compared to standard. Measured by its ability to inhibit IL1a-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 30-150ng/ml (corresponding to a specific activity of 6,667-33,334units/mg ) in the presence of 50pg/ml of rrIL1a.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 17.5 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

HPAGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNT KLEEKIDMVP IDFRNVFLGI HGGKLCLSCV KSGDDTKLQL EEVNITDLNK NKEEDKRFTF IRSETGPTTS FESLACPGWF LCTTLEADHP VSLTNTPKEP CTVTKFYFQE DQ

Storage Instruction

Lyophilized IL 1RA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL 1RA should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized IL 1RA in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rIL1RA
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