RHEB

Alternative Names: Ras homolog enriched in brain, Ras homolog enriched in brain, GTP-binding protein Rheb, Ras homolog enriched in brain GTP binding protein Rheb, Ras homolog enriched in brain 2, RHEB 2, RHEB2, RheB.

RHEB is a member of the Ras & GTPase superfamily found in various tissues, but first identified as an immediate-early gene in the brain. It encodes a lipid-anchored protein in the cell membrane with five repeats of the RAS-related GTP-binding region. RHEB plays a crucial role in regulating growth and cell cycle progression through the TOR/S6K signaling pathway. Its GTPase activity allows it to switch between GDP-bound and GTP-bound forms, and farnesylation is necessary for this activity. RHEB has been found to promote oncogenic transformation and is associated with prostate cancer and lymphomagenesis. Moreover, RHEB serves as a useful diagnostic tool to distinguish between fibroadenoma and malignant breast carcinomas. Additionally, RHEB has a key function in regulating the Ras/B-Raf/C-Raf/MEK signaling network.

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  • Sku: PSB-pro-308-10µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Ras Homolog Enriched in Brain (RHEB) is a protein belonging to the Ras superfamily, specifically the small GTPase family. With a molecular weight of approximately 23 kDa, RHEB plays a significant role in cellular processes such as cell growth, proliferation, and metabolism. This protein is involved in the regulation of the mammalian target of rapamycin (mTOR) signaling pathway, which is crucial for cell survival and growth. Understanding the functions and mechanisms of RHEB can provide valuable insights into various neurological disorders and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The RHEB protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MASMTGGQQM GRGSASMPQS KSRKIAILGY RSVGKSSLTI QFVEGQFVDS YDPTIENTFT KLITVNGQEY HLQLVDTAGQ DEYSIFPQTY SIDINGYILV YSVTSIKSFE VIKVIHGKLL DMVGKVQIPI MLVGNKKDLH MERVISYEEG KALAESWNAA FLESSAKENQ TAVDVFRRII LEAEKMDGAA SQGKSSC.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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RHEB
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