RGS5

Alternative Names: RGS5, Regulator of G-protein signaling 5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129.

Regulator of G-protein signaling 5 (RGS5) is a protein that directly binds to activated G alpha subunits and acts as a GTPase-activating protein (GAP). This protein weakens and/or modulates hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. RGS5 is expressed in vascular endothelial cells and is associated with capillary morphogenesis, suggesting its involvement in capillary growth, angiogenesis, and potentially stroke pathophysiology.

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  • Sku: PSB-pro-905-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Regulator of G-Protein Signaling 5 (RGS5) is a protein that belongs to the RGS family, which acts as negative regulators of G-protein coupled receptor signaling pathways. With a molecular weight of approximately 24 kDa, RGS5 plays a significant role in modulating intracellular signaling cascades by accelerating the GTPase activity of Gα subunits, thereby terminating G-protein signaling. This recombinant protein is widely utilized in scientific research to investigate the intricate mechanisms underlying G-protein coupled receptor signaling and its potential implications in various physiological and pathological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
23.5 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation RGS5 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMCKGLA ALPHSCLERA KEIKIKLGIL LQKPDSVGDL VIPYNEKPEK PAKTQKTSLD EALQWRDSLD KLLQNNYGLA SFKSFLKSEF SEENLEFWIA CEDYKKIKSP AKMAEKAKQI YEEFIQTEAP KEVNIDHFTK DITMKNLVEP SLSSFDMAQK RIHALMEKDS LPRFVRSEFY QELIK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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RGS5

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