RGS4

Alternative Names: RGS4, Regulator of G-protein signaling 4, SCZD9, RGP4.

Regulator of G protein signaling 4 (RGS4) is a member of the RGS family of regulatory molecules that control G protein signaling. RGS proteins function as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. These G proteins play a crucial role in transmitting signals from cell surface receptors to intracellular effectors.

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  • Sku: PSB-pro-900-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Regulator of G-Protein Signaling 4 (RGS4) is a protein that belongs to the RGS protein family, which plays a crucial role in regulating G-protein signaling pathways. RGS4 acts as a negative regulator of G-proteins, specifically targeting Gαi/o subunits, thereby attenuating their signaling activity. With a molecular weight of approximately 24 kDa, RGS4 is involved in modulating various cellular processes, including neurotransmission, cell proliferation, and differentiation. Its precise regulatory mechanisms make RGS4 an important protein for understanding and potentially manipulating G-protein signaling pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
25.4 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation RGS4 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 10% glycerol and 200mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL VPQCA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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RGS4

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