RGS2

Alternative Names: 1. Breast Cancer Metastasis Suppressor

The BRMS1 protein, a member of the mSin3a family of HDAC complexes, is primarily found in the nucleus. It contains two coiled-coil motifs and a few imperfect leucine zipper motifs. BRMS1 reduces the metastatic potential of melanoma cell lines and human breast cancer, without affecting tumorogenicity. Alternative splicing gives rise to two transcript variants that produce different isoforms.

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  • Sku: PSB-pro-182-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Regulator of G-Protein Signaling 2 (RGS2) is a protein that belongs to the RGS family, which plays a vital role in regulating G-protein signaling pathways. With a molecular weight of approximately 24 kilodaltons, RGS2 acts as a negative regulator by accelerating the GTPase activity of G-alpha subunits, thereby attenuating G-protein coupled receptor signaling. This protein's significance lies in its ability to modulate various physiological processes, including neurotransmission, cardiovascular function, and immune response. By precisely controlling G-protein signaling, RGS2 contributes to maintaining cellular homeostasis and overall organismal health.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 80% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The BRMS1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MASMTGGQQM GRGSHMPVQP PSKDTEEMEA EGDSAAEMNG EEEESEEERS GSQTESEEES SEMDDEDYER RRSECVSEML DLEKQFSELK EKLFRERLSQ LRLRLEEVGA ERAPEYTEPL GGLQRSLKIR IQVAGIYKGF CLDVIRNKYE CELQGAKQHL ESEKLLLYDT LQGELQERIQ RLEEDRQSLD LSSEWWDDKL HARGSSRSWD SLPPSKRKKA PLVSGPYIVY MLQEIDILED WTAIKKARAA VSPQKRKSDG P

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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RGS2

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