RGS17

Alternative Names: RGS-17, RGSZ2, hRGS17, Regulator of G-protein signaling 17

RGS17 decreases the signaling activity of G-proteins by binding to activated GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), which speeds up the conversion of GTP to GDP. This process enables the binding of G alpha subunits to G beta/gamma subunit heterodimers, resulting in the formation of inactive G-protein heterotrimers and the termination of the signal. RGS17 plays a critical role in ending the signaling by mu opioid receptors and the development of tolerance to opioid analgesic drugs.

  •
  • Sku: PSB-pro-924-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Regulator of G-Protein Signaling 17 (RGS17) is a protein that belongs to the RGS family. RGS proteins play a crucial role in regulating G-protein signaling pathways, which are involved in various cellular processes. With a weight of approximately 23 kDa, RGS17 acts as a negative regulator by accelerating the GTPase activity of Gα subunits, thereby attenuating G-protein signaling. This protein's functional significance lies in its ability to modulate intracellular signaling cascades, making it an important target for research in understanding the intricate mechanisms of cellular communication.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Heterotrimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The RGS17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl,1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV ESTAGSSSES.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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RGS17
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