rGRO b

Alternative Names: Macrophage inflammatory protein 2-alpha, MIP2-alpha, MIP2, MIP2A, MIP-2a, chemokine (C-X-C motif) ligand 2, GRO2, Growth-regulated protein beta, Gro-beta, GROb, MGSA beta, SCYB2, MGSA-b, CINC-2a, CINC-3.

CXCL2 is a small cytokine in the CXC chemokine family, also known as MIP2-alpha, Gro-beta, and Gro-2. It is closely related to CXCL1, sharing 90% amino acid sequence identity. Produced by monocytes and macrophages, CXCL2 attracts polymorphonuclear leukocytes and hematopoietic stem cells. Its gene is located on human chromosome 4 among other CXC chemokines. CXCL2 activates cells through interaction with the CXCR2 receptor on the cell surface.

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  • Sku: PSB-chm-372-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat GRO-beta/MIP-2 (CXCL2) is a chemokine protein belonging to the CXC subfamily. With a molecular weight of approximately 8.3 kDa, this protein plays a role in mediating the inflammatory response by promoting the recruitment of neutrophils to sites of infection or injury. Recombinant Rat GRO-beta/MIP-2 is commonly used in research settings to study the mechanisms of inflammation and immune response.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 99.0% by SDS-PAGE
Activity
 The biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg. The biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN.

Storage Instruction

Lyophilized GRO-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized GRO-beta Rat in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rGRO b
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