RFXANK

Alternative Names: ANKRA1, BLS, F14150_1, RFX-B, DNA-binding protein RFXANK, Ankyrin repeat family A protein 1, Regulatory factor X subunit B, Regulatory factor X-associated ankyrin-containing protein, RFXANK, RFXB.

Regulatory Factor X-Associated Ankyrin-Containing Protein (RFXANK) is a protein with ankyrin repeats that are involved in interactions with other proteins. It forms a complex with regulatory factor X-associated protein and regulatory factor-5, which binds to the X box motif found in certain MHC class II gene promoters and activates the transcription of these genes. When this complex is bound to the promoter, it also associates with the non-DNA-binding factor MHC class II transactivator. This factor controls the specificity and ability of MHC class II genes to be expressed in different cell types. Mutations in RFXANK have been associated with a type of bare lymphocyte syndrome called type II, complementation group B.

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  • Sku: PSB-pro-1537-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Product Details

Product Description

Recombinant Human Regulatory Factor X-Associated Ankyrin-Containing Protein (RH-RFXANK) is a protein that plays a vital role in gene regulation and immune system function. Belonging to the family of regulatory factor X-associated ankyrin-containing proteins, RH-RFXANK is involved in the assembly of the regulatory factor X complex, which binds to DNA and controls the expression of various genes. With a molecular weight of approximately [insert weight], RH-RFXANK serves as a critical component in the intricate machinery that governs gene transcription and immune response, highlighting its significance in cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The RFXANK solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

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RFXANK
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