rFGF21

Alternative Names: FGF-21, Fibroblast growth factor 21.

The FGFs are a group of small secreted peptides that stimulate fibroblast proliferation. They bind to FGF receptors (FGFRs) 1, 2, or 3, except for FGFR4, which can bind but does not cause cell proliferation. FGFRs play a role in regulating glucose and lipid levels, and disruptions in FGF signaling can lead to diabetes and impaired pancreatic development. FGFR4 is also involved in cholesterol metabolism and bile acid synthesis. FGF-19 has been shown to reduce obesity and improve glucose and lipid profiles in diabetic rodents. FGF-21, primarily expressed in the liver, promotes glucose uptake in adipocytes and has beneficial effects on obesity and blood glucose levels.

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  • Sku: PSB-cyt-130-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Fibroblast Growth Factor-21 (rRatFGF-21) is a protein that belongs to the fibroblast growth factor (FGF) family. With a molecular weight of approximately X kDa, rRatFGF-21 plays a significant role in regulating metabolic homeostasis. This protein exhibits potent effects on glucose and lipid metabolism, making it a promising candidate for therapeutic interventions targeting metabolic disorders. Its precise mechanism of action involves activating specific signaling pathways, such as the AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARα) pathways. Understanding the functions and properties of rRatFGF-21 contributes to advancements in metabolic research and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 The ED50 determined by a cell proliferation assay using murine NIH/3T3 cells is less than 700 ng/ml, corresponding to a specific activity of > 1.4 × 1000 IU/mg in the presence of 5µg/ml of rMuKlotho-beta.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 19.7 kDa
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

AYPISDSSPL LQFGGQVRQR YLYTDDDQDT EAHLEIREDG TVVGTAHRSP ESLLELKALK PGVIQILGVK ASRFLCQQPD GTLYGSPHFD PEACSFRELL LKDGYNVYQS EAHGLPLRLP QKDSQDPATR GPVRFLPMPG LPHEPQEQPG VLPPEPPDVG SSDPLSMVEP LQGRSPSYAS

Storage Instruction

Lyophilized FGF 21 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF 21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized FGF 21 Rat Recombinant in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rFGF21
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