rCyclophilin F

Alternative Names: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, PPIase F, Cyclophilin D, CyP-D, CypD, Cyclophilin F, Rotamase F, Ppif, Peptidyl-prolyl cis-trans isomerase F, mitochondrial, PPIase

Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Cyclophilin-F) is a protein-folding enzyme that catalyzes the rearrangement of proline imidic peptide bonds in oligopeptides. It is involved in regulating the mitochondrial permeability transition pore (mPTP) and plays a role in oxidative stress-induced necrosis, alongside mitochondrial TP53. Cyclophilin-F also modulates the activity of the mitochondrial membrane F1F0 ATP synthase and regulates adenine nucleotide levels in the mitochondrial matrix. Additionally, it has anti-apoptotic properties, independently of mPTP, and cooperates with BCL2 to inhibit cytochrome c-dependent apoptosis.

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  • Sku: PSB-enz-903-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Rat Cyclophilin-F is a protein belonging to the cyclophilin family, known for its peptidyl-prolyl cis-trans isomerase activity. This protein plays a role in protein folding and trafficking within cells. With a molecular weight of approximately 18 kDa, Recombinant Rat Cyclophilin-F is commonly used in research studies to investigate its function and potential therapeutic applications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Rat
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
21.2 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation Cyclophilin F protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSCSDGGAR GANSSSQNPL VYLDVGADGQ PLGRVVLELK ADVVPKTAEN FRALCTGEKG FGYKGSTFHR VIPAFMCQAG DFTNHNGTGG KSIYGSRFPD ENFTLKHVGP GVLSMANAGP NTNGSQFFIC TIKTDWLDGK HVVFGHVKEG MDVVKKIESF GSKSGKTSKK IVITDCGQLS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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rCyclophilin F

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