rCXCL17

Alternative Names: C-X-C motif chemokine 17, Cxcl17, Protein Cxcl17, RGD1304717, VCC-1, Vcc1, VEGF co-regulated chemokine 1

Dendritic cell and monocyte chemokinelike protein (DMC/CXCL17/VEGF-correlated chemokine 1/VCC1) is a secreted molecule with similarities to chemokines CXCL8/IL8 and CXCL14/BRAK, specifically in its size and predicted 3D folding pattern. CXCL17 is produced by airway and intestinal epithelium, attracting quiescent peripheral blood monocytes and dendritic cells, but not LPS-activated ones. It also binds to these cells. Expression of CXCL17 increases in endothelial cells during tube formation in vitro, suggesting a role in angiogenesis, similar to CXCL1/GRO and CXCL8/IL8. In tumors, CXCL17 shows significant correlation with VEGF expression, indicating potential involvement in tumor angiogenesis. Rat CXCL17 shares high sequence identity with mouse and human CXCL17.

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  • Sku: PSB-chm-281-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat VEGF Co-regulated Chemokine 1 is a member of the chemokine family, specifically known for its role in regulating vascular endothelial growth factor (VEGF) expression. This protein has a molecular weight of approximately 8.5 kDa and is involved in mediating the recruitment and activation of immune cells in response to inflammation. Recombinant Rat VEGF Co-regulated Chemokine 1 plays a significant role in angiogenesis and wound healing processes, making it a valuable tool for studying immune responses and vascular development in research settings.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Measured by its ability to induce VEGF expression in mouse endothelial cells. The ED50 for this effect is typically 1-5 µg/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 11.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, 300mM NaCl, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SPNQEVARHH GDQHQAPRRW LWEGGQECDC KDWSLRVSKR KTTAVLEPPR KQCPCDHVKG SEKKNRRQKH HRKSQRPSRT CQQFLKRCQL ASFTLPL.

Storage Instruction

Lyophilized CXCL17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rCXCL17
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