RCVRN

Alternative Names: Cancer-associated retinopathy protein, Protein CAR, Recoverin, RCVRN, RCV1.

Recoverin is a calcium sensor protein found in photoreceptor cells of the retina. It binds to calcium ions and undergoes a conformational change, allowing it to move from the solution to the disc membrane. This translocation is facilitated by the removal of an acyl group in the presence of calcium. Recoverin functions to inhibit the phosphorylation of rhodopsin, a protein involved in the termination of the phototransduction cascade. This inhibition is important for the eye's ability to adapt to and recover from exposure to light. Additionally, recoverin is a protein that can be detected in patients with cancer-associated retinopathy, a syndrome linked to cancer.

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  • Sku: PSB-pro-441-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Recoverin is a protein that belongs to the calcium-binding protein family. With a molecular weight of approximately 23 kDa, it plays a significant role in the regulation of calcium signaling in the retina. This protein is involved in the modulation of photoreceptor cell function and is particularly abundant in the rod cells. Recombinant Human Recoverin is widely studied for its potential implications in various retinal diseases and disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein (1mg/ml) contains 20mM Tris-HCl pH 8.0, 1mM EDTA, 2mM MgCl2 and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKNEVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKMKNA.

Storage Instruction

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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RCVRN
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