RCAN1

Alternative Names: Calcipressin-1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, RCAN1, ADAPT78, CSP1, DSC1, DSCR1, RCN1.

The human gene located on chromosome 21, known as RCAN1, has the ability to interact with calcineurin A and hinder calcineurin-dependent signaling pathways. This interaction may have an impact on the development of the central nervous system. RCAN1 is found in the specific region of interest for the Down syndrome phenotype and is observed to be overexpressed in the brains of Down syndrome fetuses. Overexpression of this gene over a prolonged period may contribute to the formation of neurofibrillary tangles, which are also associated with Alzheimer's disease. Additionally, three different versions of the gene, referred to as transcript variants, have been discovered, each encoding a distinct isoform. Another gene called DSCR1 has a similar role in inhibiting calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Like RCAN1, DSCR1's action may also affect the development of the central nervous system.

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  • Sku: PSB-pro-319-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Regulator of Calcineurin 1 (RCAN1) is a protein that belongs to the calcineurin inhibitor family. With a molecular weight of approximately 29 kDa, RCAN1 plays a significant role in cellular processes by modulating the activity of calcineurin, a calcium-activated phosphatase. This protein acts as a negative regulator, inhibiting the calcineurin signaling pathway, which is involved in various physiological and pathological processes. By precisely controlling calcineurin activity, RCAN1 contributes to the fine-tuning of cellular responses, making it a crucial component in maintaining cellular homeostasis.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5, 100mM NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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RCAN1
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