rCALB1

Alternative Names: Calbindin D28, Calbindin, Vitamin D-dependent calcium-binding protein, avian-type, D-28K, Spot 35 protein, Calb1, CaBP28K, MGC93326.

Calbindins are calcium-binding proteins related to the troponin C superfamily. CALB28K/Calbindin1/CALB1, originally discovered in chickens, is a protein that is induced by vitamin D and found in the duodenum. In mammals, this protein is expressed in the kidneys, pancreatic islets, and brain. Interestingly, its synthesis in the brain is not dependent on vitamin D. CABP28K consists of four active and two inactive EF-hand calcium-binding domains. The gene for CABP28K is located in the same region as carbonic anhydrase. In patients with Huntington disease, the neurons in their brain show a depletion of CAB28K. Two types of calcium-binding proteins exist: "trigger" and "buffer." "Trigger" type proteins change their conformation upon binding to calcium, leading to alterations in their activity by interacting with target molecules. On the other hand, buffer-type proteins are believed to regulate the concentration of calcium inside cells. Calbindin D-28K is predominantly found in specific groups of neurons in the central and peripheral nervous systems, as well as in certain epithelial cells involved in calcium transport in the kidney and enteric neuroendocrine cells.

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  • Sku: PSB-pro-400-1µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Rat Calbindin-1 is a protein belonging to the Calbindin family, which is characterized by its ability to bind calcium ions. This protein plays a significant role in calcium homeostasis within cells, aiding in the regulation of intracellular calcium levels. With a molecular weight of approximately 28 kDa, Recombinant Rat Calbindin-1 demonstrates a high affinity for calcium ions, facilitating their transport and buffering capacity. Its precise functions and interactions within cellular processes make Recombinant Rat Calbindin-1 a subject of interest in various scientific studies and research endeavors.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rat
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a concentrated solution (1mg/ml) containing 50mM NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

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Storage Instruction

Lyophilized CABP28K although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CABP28K should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CABP28K in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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rCALB1
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