RARRES2, His

Alternative Names: Chemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433. Reordered series: HP10433, Chemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2.

RARRES2 is a chemotactic protein that induces chemotaxis through the ChemR23 ligand. It is upregulated by the synthetic retinoid tazarotene and is found in many different tissues. RARRES2 acts as an adipokine and is structurally similar to other proteins like cathelicidin precursors, cystatin C, and kininogens. It promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. Initially, RARRES2 is secreted as a precursor with low biological activity. However, it can become a potent and highly specific agonist of ChemR23 after undergoing proteolytic cleavage of its COOH-terminal domain. RARRES2 signals through its receptor, ChemR23, to positively regulate adipocyte differentiation and metabolic function. The Chemerin receptor also serves as a coreceptor for SIV and some primary HIV-1 strains. Additionally, the Chemerin receptor has another ligand called tazarotene-induced gene.

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  • Sku: PSB-pro-1458-5µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Retinoic Acid Receptor Responder 2, His Tag is a protein that belongs to the retinoic acid receptor (RAR) family. With a molecular weight of (insert weight), this protein plays a significant role in mediating the effects of retinoic acid signaling. It functions as a transcription factor, regulating the expression of target genes involved in various biological processes. The His tag attached to this recombinant protein allows for easy purification and detection, facilitating its use in research and drug development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation RARRES2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAVDTP FPAGIFVRLE FKLQQTSCRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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RARRES2, His
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