RANGRF

Alternative Names: Ran guanine nucleotide release factor, RANGRF, Ran-binding protein MOG1, MOG1, HSPC165, HSPC236, MDS5.

RANGRF is a protein that functions as a guanine nucleotide release factor in mice and plays a role in regulating the expression and function of the Nav1.5 cardiac sodium channel in humans. Additionally, RANGRF is involved in controlling the movement of RAN within cells. Specifically in cardiac cells, RANGRF seems to be responsible for determining the presence of SCN5A on the cell surface.

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  • Sku: PSB-pro-1149-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human RAN Guanine Nucleotide Release Factor is a protein that plays a significant role in the regulation of nucleocytoplasmic transport. Belonging to the GTPase activating protein (GAP) family, this protein acts as a catalyst for the hydrolysis of GTP bound to the small GTPase RAN, thus promoting the release of RAN from its nucleotide complex. With a molecular weight of approximately X kDa, this protein is involved in the control of various cellular processes, including nuclear import and export, spindle assembly, and cell cycle progression. Its precise functions make it a key player in maintaining cellular homeostasis and ensuring proper intracellular transport.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation RANGRF protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.15M NaCl and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMEPTRD CPLFGGAFSA ILPMGAIDVS DLRPVPDNQE VFCHPVTDQS LIVELLELQA HVRGEAAARY HFEDVGGVQG ARAVHVESVQ PLSLENLALR GRCQEAWVLS GKQQIAKENQ QVAKDVTLHQ ALLRLPQYQT DLLLTFNQPP PDNRSSLGPE NLSPAPWSLG DFEQLVTSLT LHDPNIFGPQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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RANGRF

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